Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells
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چکیده
منابع مشابه
Rapamycin impairs in vivo proliferation of islet beta-cells.
BACKGROUND Progressive graft dysfunction is commonly observed in recipients of islet allografts treated with high doses of rapamycin. This study aimed at evaluating the effect of rapamycin on pancreatic islet cell proliferation in vivo. METHODS The murine pregnancy model was utilized, since a high rate of beta-cell proliferation occurs in a well-defined time frame. Rapamycin (0.2 mg/kg/day) w...
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duces proinflammatory lipids that exacerbate β cell dysfunction and death. Inhibition of 12/15-LOX thereby provides a potential therapeutic approach to prevent glycemic deterioration in T1D, but to date no specific inhibitors have been tested T1D. Here we assessed the efficacy and mechanism of a novel and specific 12/15-LOX inhibitor, ML351. Using cultured β cells in vitro, ML351 exhibited no a...
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To study effects of Bcl-x(L) in the pancreatic beta-cell, two transgenic lines were produced using different forms of the rat insulin promoter. Bcl-x(L) expression in beta-cells was increased 2- to 3-fold in founder (Fd) 1 and over 10-fold in Fd 2 compared with littermate controls. After exposure to thapsigargin (10 microM for 48 h), losses of cell viability in islets of Fd 1 and Fd 2 Bcl-x(L) ...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2020
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2020.101042